CCG-63802

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CCG-63802

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

620112-78-9

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

CCG-63802 是一种选择性，可逆变构的 G 蛋白信号调节子RGS4抑制剂。CCG-63802 与RGS4特异性结合并阻断 RGS4-Gα_o相互作用，IC₅₀值为 1.9 μM。

生物活性

CCG-63802 is a selective, reversible and allostericRGS4inhibitor. CCG-63802 specifically binds toRGS4and blocks the RGS4-Gα_ointeraction, with anIC₅₀value of 1.9 μM^[1].

IC₅₀& Target^[1]

RGS4

1.9 μM (IC₅₀)

体外研究
(In Vitro)

CCG-63802 (5 μM) inhibits regulators of G-protein signaling (RGS) proteins in the presence of BK (bradykinin) and 8-Br-cGMP (membrane-permeable analogue of cGMP), HEK-293 cells start to depolarize again^[2].

体内研究
(In Vivo)

CCG-63802 (0.05 mg/kg; intratracheal administration; once per week; 90 days) reduces RGS4 protein expression, leading to partially abrogate the attenuating effect of PGZ on airway inflammation, hyperresponsiveness (AHR), and remodeling^[3].

Animal Model:	Forty female BALB/c mice aged 6-8 week old^[3]
Dosage:	0.05 mg/kg
Administration:	Intratracheal administration; once per week; 90 days
Result:	CCG 63802 treatment in OVA +PGZ + CCG group significantly reduced RGS4 protein expression compared to OVA + PGZ group (P< 0.05)

分子量

450.51

性状

Solid

Formula

C₂₆H₁₈N₄O₂S

CAS 号

620112-78-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 1.67 mg/mL(3.71 mM;Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.2197 mL	11.0985 mL	22.1971 mL
5 mM	---	---	---
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

1.
CCG-63802 is dissolved in DMSO and diluted with 0.9% NaCl^[3].