产品介绍 目录号
Serial | TCHu191 | 标识符
Identifier | CSTR:19375.09.3101HUMTCHu191 | 描述
Description | 连续细胞株K-562由Lozzio从一位临终的53岁女性慢性骨髓性白血病患者的胸水中建立。 细胞被归入高度未分化的粒性白细胞类。 Anderson等对其表面膜性质的研究表明，K-562是一株人类红白血病细胞。 K-562细胞株在自然杀伤分析中广泛作为高敏感的体外受体。 See Pross等将它用于NK细胞的体外详细检测，包括NK细胞活性的数学量化。 K-562母细胞是多能性，造血恶性细胞，它能自发分化成可识别的红血球祖细胞、粒性白细胞、单核细胞等。它是EBNA阴性的。
在本库通过支原体检测。
在本库通过STR检测。 | 动物种别
Organism | 人 | 性别
Gender | 女 | 组织来源
Tissue and Cell Type | 骨髓；慢性骨髓性白血病(CML) | 形态
Morphology | 淋巴母细胞 | 培养基和添加剂
Complete Growth Medium and Culture Conditions | IMDM培养基(GIBCO,货号12200036)，90%；优质胎牛血清，10%。
气相：空气，95%；二氧化碳，5%。
温度：37摄氏度。 | 供应限制
Permits and Restrictions | A。仅供研究之用。 | | REFERENCE | Koeffler HP , Golde DW . Human myeloid leukemia cell lines: a review. Blood 56: 344-350, 1980. PubMed: 6996765Ortaldo JR , et al. Specificity of natural cytotoxic reactivity of normal human lymphocytes against a myeloid leukemia cell line. J. Natl. Cancer Inst. 59: 77-82, 1977. PubMed: 69036Lozzio CB , Lozzio BB . Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. Blood 45: 321-334, 1975. PubMed: 163658Lozzio BB , Lozzio CB . Properties and usefulness of the original K-562 human myelogenous leukemia cell line. Leuk. Res. 3: 363-370, 1979. PubMed: 95026Andersson LC , et al. K562--a human erythroleukemic cell line. Int. J. Cancer 23: 143-147, 1979. PubMed: 367973Lozzio BB , et al. A multipotential leukemia cell line (K-562) of human origin. Proc. Soc. Exp. Biol. Med. 166: 546-550, 1981. PubMed: 7194480Dimery IW , et al. Variation amongst K562 cell cultures. Exp. Hematol. 11: 601-610, 1983. PubMed: 6576909Chan YJ , et al. Two distinct upstream regulatory domains containing multicopy cellular transcription factor binding sites provide basal repression and inducible enhancer characteristics to the immediate-early IES (US3) promoter from human cytomegalovirus. J. Virol. 70: 5312-5328, 1996. PubMed: 8764042Kolanus W , et al. alphaLbeta2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1 a cytoplasmic regulatory molecule. Cell 86: 233-242, 1996. PubMed: 8706128Gan W , Rhoads RE . Internal initiation of translation directed by the 5'-untranslated region of the mRNA for eIF4G, a factor involved in the picornavirus-induced switch from cap-dependent to internal initiation. J. Biol. Chem. 271: 623-626, 1996. PubMed: 8557663Tiffany HL , et al. Enhanced expression of the eosinophil-derived neurotoin ribonuclease (RNS2) gene requires interaction between the promoter and intron. J. Biol. Chem. 271: 12387-12393, 1996. PubMed: 8647842Chan YJ , et al. Synergistic interactions between overlapping binding sites for the serum response factor and ELK-1 proteins mediate both basal enhancement and phorbol ester responsiveness of primate cytomegalovirus. J. Virol. 70: 8590-8605, 1996. PubMed: 8970984Nauseel WM , et al. Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase. J. Biol. Chem. 271: 9546-9549, 1996. PubMed: 8621627Grune T , et al. Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome. J. Biol. Chem. 271: 15504-15509, 1996. PubMed: 8663134Jondal M , Pross H . Surface markers on human b and t lymphocytes. VI. Cytotoxicity against cell lines as a functional marker for lymphocyte subpopulations. Int. J. Cancer 15: 596-605, 1975. PubMed: 806545West WH , et al. Natural cytotoxic reactivity of human lymphocytes against a myeloid cell line: characterization of effector cells. J. Immunol. 118: 355-361, 1977. PubMed: 299761Pross HF , et al. Spontaneous human lymphocyte-mediated cytotoxicity against tumor target cells. IX. The quantitation of natural killer cell activity. J. Clin. Immunol. 1: 51-63, 1981. PubMed: 7334070Chen TR . Modal karyotype of human leukemia cell line, K562 (ATCC CCL 243). Cancer Genet. Cytogenet. 17: 55-60, 1985. PubMed: 3857109Wu SQ , et al. Extensive amplification of bcr/abl fusion genes clustered on three marker chromosomes in human leukemic cell line K-56. Leukemia 9: 858-862, 1995. PubMed: 7769849 |
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