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环指蛋白105抗体
产品介绍 靶标: TTC3 产品别名: DCRR1; RNF105; TPRDIII; TTC3; tetratricopeptide repeat domain 3; tetratricopeptide repeat domain 3; E3 ubiquitin-protein ligase TTC3; RING finger protein 105; RING-type E3 ubiquitin transferase TTC3; TPR repeat protein 3; TPR repeat protein D; tetratricopeptide repeat protein 3; 环指蛋白105; 背景信息: E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains. Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3 in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2. Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK. Inhibits cell proliferation. 宿主:Rbt |
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