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抗肌萎缩蛋白(UTRN)抗体
产品介绍 靶标: UTRN 产品别名: DMDL; DRP; DRP1; UTRN; utrophin; utrophin; utrophin; dystrophin-related protein 1; 抗肌萎缩蛋白(UTRN); 肌营养不良蛋白相关蛋白1; 背景信息: This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008], 宿主:Rbt |
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