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甲状腺激素受体相互作用12抗体
产品介绍 靶标： TRIP12 产品别名： MRD49； TRIP-12； TRIPC； ULF； TRIP12； thyroid hormone receptor interactor 12； thyroid hormone receptor interactor 12； E3 ubiquitin-protein ligase TRIP12； E3 ubiquitin-protein ligase for Arf； HECT-type E3 ubiquitin transferase TRIP12； TR-interacting protein 12； probable E3 ubiquitin-protein ligase TRIP12； thyroid receptor interacting protein 12； 甲状腺激素受体相互作用12； 背景信息： function:Component of PA700, an ATP-dependent multisubunit protein that activates the proteolytic activities of the multifunctional proteinase (20S proteasome) of the 26S complex. Specifically interacts with the ligand binding domain of the thyroid hormone receptor (in a thyroid hormone T3-independent manner) and with retinoid X receptor (RXR). Could be E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.,miscellaneous:A cysteine residue is required for ubiquitin-thioester formation.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the UPL family. K-HECT subfamily.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 1 WWE domain.,subunit:PA700 is composed of at least 16 distinct peptides ranging from 20-112 kDa., 宿主：Rbt |
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