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Bruton酪氨酸激酶抑制剂蛋白抗体
产品介绍 靶标: IBTK 产品别名: BTBD26; BTKI; IBTK; inhibitor of Bruton tyrosine kinase; inhibitor of Bruton tyrosine kinase; inhibitor of Bruton tyrosine kinase; BTK-binding protein; Bruton agammaglobulinemia tyrosine kinase inhibitor; inhibitor of Bruton's tyrosine kinase-alpha; inhibitor of Bruton's tyrosine kinase-beta; inhibitor of Bruton's tyrosine kinase-gamma; Bruton酪氨酸激酶抑制剂蛋白; 背景信息: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014], 宿主:Rbt |
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