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无精症缺失相关蛋白1抗体
产品介绍 靶标: DAZAP1 产品别名: DAZAP1; DAZ associated protein 1; DAZ associated protein 1; DAZ-associated protein 1; deleted in azoospermia-associated protein 1; testicular tissue protein Li 50; 无精症缺失相关蛋白1; 背景信息: DAZ-associated protein 1 is a protein that in humans is encoded by the DAZAP1 gene. It is mapped to19p13.3. In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. 宿主:Rbt |
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