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纺锤体和着丝粒相关蛋白2抗体
产品介绍 靶标: Ska2 产品别名: 1110001A07Rik; C78640; Fam33a; Ska2; spindle and kinetochore associated complex subunit 2; spindle and kinetochore associated complex subunit 2; spindle and kinetochore-associated protein 2; family with sequence similarity 33, member A; 纺锤体和着丝粒相关蛋白2; 背景信息: Spindle and kinetochore-associated protein 2 is a protein that in humans is encoded by the SKA2 gene found in chromosome 17.SKA2 is a part of a spindle and kinetochore associated complex also including SKA1 and SKA3 which is responsible for onset of the anaphase in mitosis by regulating chromosomal segregation. SKA2 may function as a prognostic gene marker for identifying lung cancer[3] as well as a proposed biomarker for suicidal tendencies and post-traumatic stress disorders.[4][5] The SKA2 gene contains one single-nucleotide polymorphism (SNP) rs7208505 located in the 3' UTR. This genetic variant containing a cytosine (existing in the less common allele) instead of thymine along with epigenetic modification (such as DNA methylation) is correlated with suicidal tendencies and post-traumatic stress 宿主:Rbt |
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