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环指蛋白217抗体
产品介绍 靶标: RNF217 产品别名: C6orf172; IBRDC1; OSTL; dJ84N20.1; RNF217; ring finger protein 217; ring finger protein 217; E3 ubiquitin-protein ligase RNF217; IBR domain containing 1; opposite STL; probable E3 ubiquitin-protein ligase RNF217; 环指蛋白217; 钠/钾转运ATP酶相互作用蛋白2; 背景信息: This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. 宿主:Rbt |
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