产品介绍 基因名: GCNT1 产品别名: C2GNT; C2GNT-L; C2GNT1; C2GlcNAcT; G6NT; NACGT2; NAGCT2; GCNT1; glucosaminyl (N-acetyl) transferase 1; glucosaminyl (N-acetyl) transferase 1; beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; beta-1,6-N-acetylglucosaminyltransferase; core 2 GnT; core 2 beta-1,6-N-acetylglucosaminyltransferase I; core 2 beta1,6 N-acetylglucosaminyltransferase-I; core 2 branching enzyme; core2-GlcNAc-transferase; glucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase); leukocyte type core 2 beta-1,6-N-acetylglucosaminyltransferase; GCNT1葡萄糖转移酶; 背景信息: GCNT1 is expressed in a variety of cell types, including lymphocytes and mucin-producing cells. Specifically, GCNT1 expression in leukocytes regulates the synthesis of core 2 O-glycans that carry sialyl-Lewis x (sLex) oligosaccharides, which confer high affinity binding to Selectins. Downregulation of Selectin ligand expression levels has been shown to inhibit tissue infiltration. Therefore, GCNT1 represents a potential drug target for the treatment of inflammatory disorders and other pathologies involving Selectins. 标签:His-tag |
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