蛋白质/抗原/多肽 >> 重组蛋白
重组剪接体相关蛋白62
产品介绍 基因名: SF3A2 产品别名: PRP11; PRPF11; SAP62; SF3a66; SF3A2; splicing factor 3a subunit 2; splicing factor 3a subunit 2; splicing factor 3A subunit 2; SAP 62; pre-mRNA splicing factor SF3A, subunit 2; spliceosome associated protein 62; splicing factor 3a, subunit 2, 66kD; splicing factor 3a, subunit 2, 66kDa; 剪接体相关蛋白62; 背景信息: SAP 62, also known as SF3A2 (Splicing factor 3A subunit 2), PRP11, PRPF11 or SF3a66, is a 464 amino acid protein that contains one matrin-type zinc finger and belongs to the SF3A2 family. Localized to the nucleus, SAP 62 is a subunit of the SF3A splicing factor, a heterotrimeric complex comprised of three subunits that act in tandem to mediate the binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. The SF3A complex is necessary for the conversion of 15S U2 snRNP into the active 17S protein that performs directly in pre-mRNA splicing events. Functioning as the second subunit of the complex, SAP 62 interacts with subunit 1 (SAP 114) via its N-terminus while simultaneously binding to 15S U2 snRNP via its zinc finger domain. In addition to its role in RNA splicing, SAP 62 is thought to act independently as a microtubule-binding protein. 标签:His-tag |
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