蛋白质/抗原/多肽 >> 重组蛋白
重组环指蛋白123
产品介绍 基因名: RNF123 产品别名: FP1477; KPC1; RNF123; ring finger protein 123; ring finger protein 123; E3 ubiquitin-protein ligase RNF123; Kip1 ubiquitination-promoting complex subunit 1; RING-type E3 ubiquitin transferase RNF123; kip1 ubiquitination-promoting complex protein 1; 环指蛋白123; 背景信息: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in protein-protein interactions and protein-DNA interactions. RNF123 (RING finger protein 123), also known as KPC1 (Kip1 (p27) ubiquitination-promoting complex protein 1) or FP1477, contains one RING-type zinc finger domain and one SPRY domain. Localizing to the cytoplasm, RNF123 functions as the catalytic component of the KPC complex that acts as an E3 ubiquitin-protein ligase. Specifically, RNF123 is essential for the ubiquitination and subsequent degradation of p27 during the cell cycle G1 phase. Via its N-terminus, RNF123 is known to interact with GBDR1 (another component of the KPC) and p27 (a cyclin-dependent kinase inhibitor). Due to alternative splicing events, two isoforms exist for RNF123. 标签:His-tag |
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