蛋白质/抗原/多肽 >> 重组蛋白
重组1号染色体开放阅读框49蛋白
产品介绍 基因名: Tex35 产品别名: 1700057K13Rik; Tex35; testis expressed 35; testis expressed 35; testis-expressed protein 35; testis-expressed sequence 35 protein; testis-specific conserved protein of 24 kDa; 1号染色体开放阅读框49; 背景信息: Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf49 gene product has been provisionally designated C1orf49 pending further characterization. There are four isoforms of C1orf49 that are produced as a result of alternative splicing events. 标签:His-tag |
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