产品介绍 基因名： CFAP91 产品别名： AAT1； AAT1alpha； C3orf15； CaM-IP2； MAATS1； SPATA26； SPGF51； CFAP91； cilia and flagella associated protein 91； cilia and flagella associated protein 91； cilia- and flagella-associated protein 91； AAT-1； AAT1-alpha； AMY-1-associating protein expressed in testis 1； MYCBP associated and testis expressed 1； MYCBP-associated, testis expressed 1； MYCBP-binding protein； MYCBP/AMY-1-associated testis-expressed protein 1； MYCBP/AMY-1-associated, testis expressed 1； protein MAATS1； spermatogenesis associated 26； 3号染色体开放阅读框15； 背景信息： The c-Myc proto-oncogene plays a significant role in cell proliferation, differentiation, transformation and apoptosis. A novel c-Myc binding protein, MYCBP (also designated AMY-1), binds to the transactivation domain of c-Myc and stimulates the activation of E-box-dependent transcription. MYCBP translocates from the cytoplasm to the nucleus during S phase when increased expression of c-Myc occurs. MYCBP and AAT-1 (AMY-1-associating protein expressed in testis 1) have been shown to associate with AKAP 149 and AKAP 84 in mitochondria of somatic cells and sperm, which suggests a role for MYCBP and AAT-1 in spermatogenesis. Expression of the AAT-1 gene is regulated by two different promoters, which result in various isoforms. One promoter generates expression of the AAT-1, AAT-1å, AAT-1∫ and AAT-1© isoforms, which are specifically expressed in testis, while the other promoter generates AAT-1L, AAT-1M and AAT-1S, which are differentially expressed. 标签：His-tag |
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