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Polyphyllin D
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Polyphyllin D图片
CAS NO:55916-51-3
包装:20mg
市场价:1722元

产品介绍
Polyphyllin D 是一种活性皂苷,具有抗癌活性。 Polyphyllin D 诱导 G2/M 细胞周期停滞并引发细胞凋亡。 Polyphyllin D 通过诱导 ROS/NF-κB/NLRP3/GSDMD 信号轴在非小细胞肺癌中诱导 caspase-1 介导的细胞焦亡。
Cas No.55916-51-3
别名重楼皂苷VI
化学名Chonglou saponin VI
Canonical SMILESO[C@@H]([C@@H](O)[C@H]1O)[C@]([H])(O[C@H]2[C@@](O[C@H]3CC4=CC[C@]([C@](C[C@@](O[C@]5(OC6)CC[C@H]6C)([H])[C@]7(O)[C@@H]5C)([H])[C@@]7(CC8)C)([H])[C@@]8([H])[C@]4(CC3)C)([H])O[C@H](CO)[C@@H](O)[C@@H]2O)C[C@@H]1C
分子式C39H62O13
分子量738.91
溶解度≥ 73.9mg/mL in EtOH with gentle warming
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Polyphyllin VI, an active saponin mainly isolated from traditional medicinal plant Paris polyphylla, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis[1][2].

References:
[1]. Lin Z, et al. Anti-lung Cancer Effects of Polyphyllin VI and VII Potentially Correlate with Apoptosis In Vitro and In Vivo. Phytother Res. 2015 Oct;29(10):1568-76.
[2]. Liu Y, et al. Molecular Mechanisms of Apoptosis in HepaRG Cell Line Induced by Polyphyllin VI via the Fas Death Pathway and Mitochondrial-Dependent Pathway. Toxins (Basel). 2018 May 15;10(5). pii: E201.