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Kaempferol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Kaempferol图片
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
山奈酚 (Kempferol) 是一种在许多可食用植物中发现的类黄酮,通过激活 MEK-MAPK 抑制乳腺癌细胞中雌激素受体 α 的表达并诱导胶质母细胞瘤细胞和肺癌细胞凋亡。山奈酚可用于乳腺癌的研究。

Cell lines

The human cholangiocarcinoma (CCA) cell lines HCCC9810 and QBC939

Preparation method

The solubility of this compound in DMSO is >12.3mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

0, 30, 60, 90, 120, or 150 μM; 24, 48, or 72 h; 37℃

Applications

In CCA cells, kaempferol significantly inhibited the viability and proliferation of CCA cells in a time- and dose-dependent way. Kaempferol reduced the number of colonies and induced apoptosis in a dose-dependent way. Kaempferol also reduced the migration and invasion ability of CCA cells in a dose-dependent manner.

Animal models

subcutaneous xenograft nude mice model

Dosage form

20 mg/kg/day; daily for 3 weeks; i.p.

Application

In subcutaneous xenograft nude mice model, kaempferol significantly inhibited the growth of the tumor. The number of Ki-67-positive tumor cells was lower in kaempferol-treated group than that in the control group. Kaempferol reduced the average volume and number of foci per mouse.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

产品描述 Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca2+ uniporter (EC50 = 7 μM). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro.