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HA 130
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HA 130图片
CAS NO:1229652-21-4
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
HA 130 是一种选择性 autotaxin (ATX) 抑制剂,IC50 为 28 nM。
Cas No.1229652-21-4
化学名(Z)-(4-((4-((3-(4-fluorobenzyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)methyl)phenyl)boronic acid
Canonical SMILESFC1=CC=C(C=C1)CN2C(/C(SC2=O)=C/C(C=C3)=CC=C3OCC4=CC=C(B(O)O)C=C4)=O
分子式C24H19BFNO5S
分子量463.29
溶解度DMF: 10 mg/mL,DMSO: 5 mg/mL,Ethanol: 0.5 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM.

HA130 completely blocks the ability of ATX to promote TEM (transendothelial migration). HA130 at 0.3 μM completely ablates the activity of ATX on TK1 uropod formation[1].

HA130 slows T cell migration across lymph node HEVs. HA130 decreases the "outside HEVs/inside HEVs" ratio by 3-4-fold compared to vehicle-treated animals vehicle[1].The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs)[2].

References:
[1]. Zhang Y, et al. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15;189(8):3914-3924.
[2]. Bai Z, et al. Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by theautotaxin/lysophosphatidic acid axis. J Immunol. 2013 Mar 1;190(5):2036-2048.