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Ro 20-1724
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ro 20-1724图片
CAS NO:29925-17-5
包装与价格：
包装价格(元)
10mM (in 1mL EtOH)电议
50mg电议

产品介绍
Ro 20-1724 (Ro 20-174) 是一种有效的 cAMP 特异性磷酸二酯酶 (PDE4/PDE IV) 抑制剂，Ki 为 1930 nM。
Cas No.29925-17-5
别名4-(3-丁氧基-4-甲氧基苯基)咪唑啶-2-酮,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
化学名(S)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one
Canonical SMILESO=C(NC1)N[C@H]1CC(C=C2OCCCC)=CC=C2OC
分子式C15H22N2O3
分子量278.35
溶解度25 mg/mL in DMSO, 30 mg/mL in DMF, 25 mg/mL in Ethanol
储存条件Store at- 20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM).[1],[2] It weakly inhibits PDE3 with a Ki value greater than 25 μM.1 Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species.[3] It is often used to study cAMP-related functions in vascular cells.[4]

Reference:
[1]. Reeves, M.L., Leigh, B.K., and England, P.J. The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors. Biochemistry Journal 241, 535-541 (1987).
[2]. Soderling, S.H., Bayuga, S.J., and Beavo, J.A. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proceedings of the National Academy of Sciences of the United States of America 95, 8991-8996 (1998).
[3]. Totani, L., Piccoli, A., Dell'Elba, G., et al. Phosphodiesterases type-4 blockade prevents platelet-mediated neutrophil recruitment at the site of vascular injury. Arteriosclerosis, Thrombosis, and Vascular Biology 34(8), 1689-1696 (2014).
[4]. Zhai, K., Hubert, F., Nicolas, V., et al. β-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PLoS One 7(10), 1-13 (2012).