Retro-2 (RN 1-001) 是一种二氢喹唑啉酮 (DHQZ) 逆行贩运抑制剂。
| Cas No. | 1429192-00-6 |
| 别名 | RN 1-001 |
| 化学名 | 2,3-dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone |
| Canonical SMILES | O=C1C2=CC=CC=C2NC(C3=CC=C(C)S3)N1C4=CC=CC=C4 |
| 分子式 | C19H16N2OS |
| 分子量 | 320.4 |
| 溶解度 | DMSO : ≥ 125 mg/mL (390.13 mM);Water :< 0.1 mg/mL (insoluble) |
| 储存条件 | Store at -20℃, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Retro-2 is a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface between the endosome and trans-Golgi network, with no discernable effects on other intracellular trafficking pathways. Retro-2 inhibits ebolavirus infection with an EC50 value of 12.2 uM and reduces ricin-induced toxicity by 2.7-fold when used at a concentration of 20 uM in HeLa cells. Retro-2 also blocks JC polyomavirus, BK polyomavirus, and SV40 infectivity in Vero green monkey kidney epithelial cells in vitro (EC50s = 28.4, 61.2, and 58.6 uM, respectively). In mouse models, Retro-2 improves survival and reduces symptoms following infection with Shiga toxin-producing E. coli when administered at a dose of 100 mg/kg and protects against ricin challenge when administered prophylactically at a dose of 2 mg/kg. |
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