Chrysomycin B 是一种从链霉菌菌株中分离出来的抗生素。 Chrysomycin B 在人肺腺癌 A549 细胞系中引起 DNA 损伤并抑制拓扑异构酶 II。 Chrysomycin B 抑制小鼠可移植肿瘤的生长。
| Cas No. | 83852-56-6 |
| 别名 | 金黄霉素B |
| 化学名 | 4-(6-deoxy-3-C-methyl-β-gulopyranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-6H-benzo[d]naphtho[1,2-b]pyran-6-one |
| Canonical SMILES | O=C(O1)C2=C(C(OC)=CC(C)=C2)C3=C1C4=C(C5OC(C)C(O)C(C)(O)C5O)C=CC(O)=C4C(OC)=C3 |
| 分子式 | C27H28O9 |
| 分子量 | 496.5 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Chrysomycin B is an antibiotic isolated from a strain of Streptomyces. It differs from its analog chrysomycin A by having a methyl, rather than vinyl, group in the 8-position of the chromophore. Like its analog, chrysomycin B suppresses the growth of transplantable tumors in mice, an effect that may be related to its ability to bind DNA. It also causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II. Chrysomycin B is structurally very similar to gilvocarcin V, which promotes DNA cross-linking with histone 3 and GRP78 when photoactivated by near-UV light. |
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