Bafilomycin B1 是一种从 Streptomyces sp 中分离出来的大环内酯类抗生素，可抑制革兰氏阳性细菌和真菌，并作为 K+- 依赖于大肠杆菌的 ATPase 的抑制剂。
| Cas No. | 88899-56-3 |
| 别名 | 巴佛洛霉素 B1 |
| Canonical SMILES | C[C@H]([C@@](C[C@H]1OC(/C=C/C(NC(C(CC2)=O)=C2O)=O)=O)(O[C@H](C(C)C)[C@H]1C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C3)=O)([H])[C@H](/C=C/C=C3\C)OC)C |
| 分子式 | C44H65NO13 |
| 分子量 | 816 |
| 溶解度 | DMSO: Soluble,Methanol: Unstable |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | The bafilomycins are fungal plecomacrolide antibiotics with a 16-membered lactone ring. They inhibit the growth of Gram-positive bacteria and fungi. Bafilomycin B1 is a selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases), blocking these proton pumps in mammalian, plant, or fungal cells with an IC50 value in the 4-400 nM range. It is at least 1,000-fold less potent at most other types of ATPases. When used at 100 nM, the related macrolide bafilomycin A1 blocks V-ATPase-mediated acidification of lysosomes during autophagy, preventing protein degradation. Remarkably, at only 1 nM, both bafilomycin A1 or B1 dramatically attenuate chloroquine-induced apoptosis of neurons without altering autophagy. |
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