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Resistomycin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Resistomycin图片
CAS NO:20004-62-0
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Restomycin 是一种五环聚酮化合物抗生素,具有抗癌活性并诱导细胞凋亡。
Cas No.20004-62-0
别名抗霉素,Antibiotic A-3733A,Heliomycin
化学名3,5,7,10-tetrahydroxy-1,1,9-trimethyl-2H-benzo[cf]pyrene-2,6(1H)-dione
Canonical SMILESO=C1C(C)(C)C2=C3C4=C(C(O)=CC(C)=C4C(O)=C2)C(C5=C(O)C=C(O)C1=C53)=O
分子式C22H16O6
分子量376.4
溶解度Soluble in DMSO;dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Resistomycin is a natural antibiotic.

Resistomycin is a natural antibiotic produced by several actinobacteriae, such as Streptomyces.

In vitro: Resistomycin, a tetrahydroxyanthrone derivative, was isolated from the culture broth of Streptomyces sulphureus and a similar polyphenolic dianthraquinone, hypericin, was isolated from an extract of Hypericum perforatum L. as modulators for apoptosis. In human megakaryoblastic leukemia CMK-7 cells, resistomycin could inhibit apoptosis induced by actinomycin D (AD) with or without acceleration by colcemid (CL), IC50 for inhibition against AD-induced apoptosis was about 0.5 μM and IC50 for inhibition against AD plus CL-induced apoptosis was about 1 μM. CL alone induced weak apoptosis in cells, which could be enhanced by resistomycin. Moreover, it was found that both hypericin and resistomycin were able to scavenge superoxide anion radicals at the same rate as luteolin. In addition, PKC in CMK-7 cells could be inhibited by hypericin and luteolin, but not obviously inhibited by resistomycin [1].

In vivo: Up to now, there is no animal in vivo data reported.

Clinical trial: So far, no clinical study has been conducted.

Reference:
[1] Shiono, Y. ,Shiono, N.,Seo, S., et al. Effects of polyphenolic anthrone derivatives, resistomycin and hypercin, on apoptosis in human megakaryoblastic leukemia CMK-7 cell line. Z. Naturforsch. C. 57(9-10), 923-929 (2002).