| In Vitro | In vitro activity: ATB-346, a structural analog of naproxen (one of the NSAIDs-Nonsteroidal anti-inflammatory drugs), is anti-inflammatory agent. ATB-346 was as effective as naproxen in adjuvant-induced arthritis in rats, with a more rapid onset of action.
Kinase Assay:
Cell Assay: |
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| In Vivo | In a mouse airpouch model, ATB-346 suppressed cyclooxygenase-2 activity and inhibited leukocyte infiltration more effectively than naproxen. ATB-346 was as effective as naproxen in adjuvant-induced arthritis in rats, with a more rapid onset of activity. Unlike naproxen, ATB-346 did not elevate blood pressure in hypertensive rats. Treatement with ATB-346 exhibited a significantly more rapid and sustained recovery of motor function, achieving greater than double the increase in locomotion score of the naproxen group by the 10th day of treatment. ATB-346 also significantly reduced the severity of inflammation (proinflammatory cytokines, apoptosis of neural tissue, and nitrosative stress) that characterized the secondary effects of SCI (spinal cord injury). |
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| Animal model | Rats with adjuvant-induced arthritis; Mice with ulcer |
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| Formulation & Dosage | P.O. |
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| References | FASEB J. 2013 Nov;27(11):4489-99; Br J Pharmacol. 2010 Mar;159(6):1236-46. |
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