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2Ɖ'-cGAMP(sodium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2Ɖ'-cGAMP(sodium salt)图片
包装与价格：
包装价格(元)
500μg电议
1mg电议

产品介绍
Canonical SMILESO=P1([O-])O[C@]([C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O4)([H])[C@@]4([H])COP(O[C@@]5([H])[C@H](N6C=NC7=C6NC(N)=NC7=O)O[C@]([C@H]5O)([H])CO1)([O-])=O.[Na+].[Na+]
分子式C20H22N10O13P2•2Na
分子量718.4
溶解度Water: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2'3'-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA. It contains a non-canonical 2'5'-phosphodiester bond and binds tightly to the adapter protein STING (stimulator of interferon genes) with a Kd value of 3.79 nM, which is significantly lower than that observed for 2'2'-cGAMP, 3'3'-cGAMP , cyclic di-GMP , and 3'2'-cGAMP (Kds = 0.287, 1.04, 1.21, and 1.61 &#181M, respectively). It is a potent inducer of IFN-β mRNA expression with an EC50 value of 19.4 nM in L929 cells.