您好，欢迎来到试剂信息网！ [登录] [免费注册]
试剂信息网
发布求购
位置：首页 > 产品库 > 4,6-Dioxoheptanoic acid
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
4,6-Dioxoheptanoic acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
4,6-Dioxoheptanoic acid图片
CAS NO:51568-18-4
包装与价格：
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
4,6-Dioxoheptanoicacid是一种有效的血红素生物合成抑制剂。
Cas No.51568-18-4
别名4,6-二氧代庚酸
Canonical SMILESCC(=O)CC(=O)CCC(O)=O
分子式C7H10O4
分子量158.15
溶解度DMSO : 100 mg/mL (632.31 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

4,6-Dioxoheptanoic acid is a potent inhibitor of heme biosynthesis.

4,6-Dioxoheptanoic acid (Succinylacetone, SA) is examined with regard to its ability to a) inhibit the second enzyme of the heme pathway, δ-aminolevulinic acid (ALA) dehydratase, b) lower the heme concentration, and c) inhibit cell growth of murine erythroleukemia (MEL) cells in culture[1].

[1]. Ebert PS, et al. Succinylacetone, a potent inhibitor of heme biosynthesis: effect on cell growth, heme contentand delta-aminolevulinic acid dehydratase activity of malignant murine erythroleukemia cells. Biochem Biophys Res Commun. 1979 Jun 27;88(4):1382-90.