MS159

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MS159

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
50mg	电议

产品介绍

MS159 是一种有效的核受体结合 SET 结构域蛋白 2 (NSD2)PROTAC降解剂。MS159 可以抑制肿瘤细胞的生长。MS159 是一种探索 NSD2 在健康和疾病中作用的有效化学工具。

生物活性

MS159 is a potent nuclear receptor binding SET structural domain protein 2 (NSD2)PROTACdegrader. MS159 inhibits the growth of tumour cells. MS159 is a useful chemical tool for exploring the role of NSD2 in health and disease^[1].

体外研究
(In Vitro)

MS159 (0.5-10 μM, 48 h) can induce the degradation of NSD2 protein in a time- and dose-dependent manner while the induced NSD2 degradation is reversible in 293FT cells^[1].
MS159 (2.5 μM, 72 h) can effectively degrade NSD2 as well as IKZF1 and IKZF3 in multiple myeloma cell lines KMS11 and H929 while the degradation of IKZF1/3 is mediated through a ubiquitin-proteasome system (UPS-) and cereblon (CRBN-) dependent mechanism^[1].
MS159 (2.5 μM, 8 days) can effectively inhibit the growth of KMS11 and H929 multiple myeloma cells through induced NSD2 degradation^[1].

Western Blot Analysis^[1]

Cell Line:	293FT cells
Concentration:	0.5-10 μM
Incubation Time:	0-72 hours
Result:	Resulted in binding affinity for the NSD2-PWWP1 structural domain with a K_dvalue of 1.1 μM, and induced degradation of NSD2 with the DC₅₀value of 5.2 μM after 48 hours.

分子量

828.83

性状

Solid

Formula

C₄₃H₄₀N₈O₁₀

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

DMSO : 50 mg/mL(60.33 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.2065 mL	6.0326 mL	12.0652 mL
5 mM	0.2413 mL	1.2065 mL	2.4130 mL
10 mM	0.1207 mL	0.6033 mL	1.2065 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。