PROTACSOS1 degrader-3 is a potentPROTACSOS1degrader.PROTACSOS1 degrader-3 effectively targeted SOS1 for degradation through the ubiquitin-proteasome system^[1].

PROTAC SOS1 degrader-3 (P7; 0.1-10 μM; 6 hours) induces SOS1 degradation in SW620 cells. In addition to SW620, PROTAC SOS1 degrader-3 also induces SOS1 degradation in other colorectal cancer (CRC) cell lines HCT116, C2BB, and SW1417 in a concentration-dependent manner. The half maximal degradation concentration (DC₅₀) for SW620, HCT116, and SW1417 at 24 h is 0.59 μM, 0.75 μM, and 0.19 μM, respectively^[1].

691.66

C₃₄H₃₂F₃N₇O₆

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