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HUHS015
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HUHS015图片
CAS NO:1453097-13-6
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW) 318.37
Formula C19H18N4O
CAS No. 1453097-13-6
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: ≥ 34 mg/mL
Water: <1 mg/mL
Ethanol:
SMILES Code OC1=C(CC2=CC=CC=C2)C(C)=NN1C3=NC4=CC(C)=CC=C4N3
Synonyms HUHS015; HUHS 015; HUHS-015
实验参考方法
In Vitro

In vitro activity: HUHS015 is a novel and potent inhibitor of PCA-1/ALKBH3 (prostate cancer antigen-1/AlkB Homolog 3) both in vitro and in vivo that was discovered from the optimization of a hit compound identified during random screening using a recombinant PCA-1/ALKBH3. The bioavailability (BA) of HUHS015 was 7.2% in rats after oral administration. Continuously administering HUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects.


Kinase Assay:


Cell Assay:

In VivoHUHS015 significantly suppressed the growth of DU145 cells, which are human hormone-independent prostate cancer cells, in a mouse xenograft model without untoward effects.
Animal modelMouse xenograft model
Formulation & Dosage
References Bioorg Med Chem Lett. 2014 Feb 15;24(4):1071-4.