SJF620 hydrochloride is aPROTACconnected by ligands forCereblonandBtkwith aDC₅₀of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN^[1].

SJF620 hydrochloride is a PROTAC that retains potent degradation of BTK in cellular assays with a DC₅₀of 7.9 nM in Burkitt lymphoma cell line NAMALWA^[1].

SJF620 hydrochloride has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with the half life (t_1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802^[1].

797.30

Solid

C₄₁H₄₅ClN₈O₇

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)