Dovitinib-D8 (CHIR-258-D8) is the deuterium labeled Dovitinib. Dovitinib (CHIR-258) is a multi-targeted tyrosine kinase inhibitor withIC₅₀s of 1, 2, 8/9, 10/13/8, 27/210 nM forFLT3,c-Kit,FGFR1/FGFR3,VEGFR1/VEGFR2/VEGFR3andPDGFRα/PDGFRβ, respectively^[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

400.48

C₂₁H₁₃D₈FN₆O

1246819-84-0

多韦替尼 D8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.