| CAS NO: | 915769-50-5 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 生物活性 | Dovitinib lactate hydrate (TKI258 lactate hydrate) is a multi-targeted tyrosine kinase inhibitor withIC50s of 1, 2, 8/9, 10/13/8, 27/210 nM forFLT3,c-Kit,FGFR1/3,VEGFR1/2/3andPDGFRα/β, respectively[1]. | |||||||||
| IC50& Target[1] |
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| 体外研究 (In Vitro) | Dovitinib potently inhibits the FGF-stimulated growth of WT and F384L-FGFR3-expressing B9 cells with IC50values of 25 nM. B9-MINV cells are resistant to the inhibitory activity of Dovitinib at concentrations up to 1 μM. Dovitinib inhibits cell proliferation of KMS11 (FGFR3-Y373C), OPM2 (FGFR3-K650E), and KMS18 (FGFR3-G384D) cells with IC50of values of 90 nM (KMS11 and OPM2) and 550 nM, respectively[1]. | |||||||||
| 体内研究 (In Vivo) | Dovitinib (10 mg/kg, 30 mg/kg, 60 mg/kg, p.o.) shows significant antitumor effect in the KMS11-bearing mice model, and the growth inhibition is 48%, 78.5%, and 94% in the 10 mg/kg, 30 mg/kg, and 60 mg/kg treatment arms, respectively, compared with the placebo-treated mice[1]. | |||||||||
| Clinical Trial | ||||||||||
| 分子量 | 500.52 | |||||||||
| Formula | C24H29FN6O5 | |||||||||
| CAS 号 | 915769-50-5 | |||||||||
| 中文名称 | 多韦替尼乳酸盐水合物 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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