| CAS NO: | 160098-96-4 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 345.36 |
|---|---|
| Formula | C18H15N7O |
| CAS No. | 160098-96-4 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 69 mg/mL (199.79 mM) |
| Water: <1 mg/mL | |
| Ethanol: N/A | |
| Solubility (In vivo) | Chemical Name: 2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine InChi Key: UTLPKQYUXOEJIL-UHFFFAOYSA-N InChi Code: InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22) SMILES Code: NC1=NC(N(CCC2=CC=CC=C2)N=C3)=C3C4=NC(C5=CC=CO5)=NN14 |
| Synonyms | SCH-58261; SCH 58261; SCH58261 |
| In Vitro | In vitro activity: NK cells were cultured in NK cell media and preincubated with or without 1 uM SCH58261 30 min before simulation with indicated concentrations of IL-18 (R & D Systems) and IL-12p70 (Australian Biosearch) in the presence or absence of NECA (1 uM) or CGS-21680 (100 nM). Kinase Assay: SCH 58261 is a novel, potent, selective and competitive antagonist of adenosine A2A receptor with an IC50 of 15 nM, and displays 323-, 53- and 100-fold more selective for A2A receptor than A1, A2B, and A3 receptors, respectively Cell Assay: SCH 58261 decreases cell viability in a concentration-dependent in the NSCLC cell line H1975. |
|---|---|
| In Vivo | It was demonstrated that the selective antagonist of the A2A receptor, SCH58261, administered i.p. starting from the early minutes after ischemia induction, reduces ischemic brain damage and neurological deficit 24 h thereafter. vehicle-rats received saline with Tween 80 (1 %) administered (i.p.) .SCH58261 (0.01 mg/kg, i.p.), administered twice/day for 7 days. |
| Animal model | Rat |
| Formulation & Dosage | Dissolved in Tween 80 (1 %) and administered (0.01 mg/kg, i.p.) twice/day for 7 days. |
| References | J Neuroinflammation. 2011 Apr 12;8:31. |
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