Picrasidine Q 是从当归植物中提取的生物碱成分，具有抗细胞转化和抗癌作用。Picrasidine Q 诱导人食管癌细胞凋亡和G1 期阻滞，并直接抑制FGFR2激酶活性。
| 生物活性 | Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cellapoptosisand G1 phase arrest in human esophagealcancercell lines, and directly inhibitsFGFR2kinase activity[1]. |
| IC50& Target[1] | |
体外研究
(In Vitro) | Picrasidine Q (0~60 μM; 3 hours; ESCC cells) suppresses downstream signaling of FGFR2 in ESCC cells[1].
Picrasidine Q (0~60 μM; 48 and 72 hours; ESCC cells) induces cell cycle arrest and apoptosis[1].
Picrasidine Q (0~60 μM; 24~72 hours; ESCC cells) suppresses the growth of ESCC cells[1].
Picrasidine Q (0~60 μM; 30 minutes; JB6Cl41 cells) inhibits proliferation by inhibition of G1/S cell cycle transition[1].
Picrasidine Q (12.5, 25 or 50 μM) can inhibit the FGFR2 kinase activity in a dose-dependent manner[1].
Western Blot Analysis[1] | Cell Line: | ESCC cells | | Concentration: | 0~60 μM | | Incubation Time: | 3 hours | | Result: | Suppressed downstream signaling of FGFR2 in ESCC cells. |
Apoptosis Analysis[1] | Cell Line: | ESCC cells | | Concentration: | 0~60 μM | | Incubation Time: | 48 and 72 hours | | Result: | Induced cell cycle arrest and apoptosis. |
Cell Cytotoxicity Assay[1] | Cell Line: | ESCC cells | | Concentration: | 0~60 μM | | Incubation Time: | 24~72 hours | | Result: | Suppressed the growth of ESCC cells. |
Cell Cycle Analysis[1] | Cell Line: | JB6Cl41 cells | | Concentration: | 0~60 μM | | Incubation Time: | 30 minutes | | Result: | Inhibited proliferation by inhibition of G1/S cell cycle transition. |
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| 分子量 | |
| Formula | |
| CAS 号 | |
| 结构分类 | - Alkaloids
- Quinoline Alkaloids
- Alkaloids
- Indole Alkaloids
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| 来源 | |
| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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