FGFR1 inhibitor-6 是一种有效的 FGFR1 抑制剂，IC50值为 16.31 nM。FGFR1 inhibitor-6 显示出细胞毒活性。FGFR1 inhibitor-6 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在前 G1 和 G2/M 期。
| 生物活性 | FGFR1inhibitor-6 is a potentFGFR1inhibitor with anIC50value of 16.31 nM.FGFR1inhibitor-6 shows cytotoxic activities.FGFR1inhibitor-6 inducesapoptosisand cell cycle arrest at pre-G1 and G2/M phase[1]. |
| IC50& Target[1] | |
体外研究
(In Vitro) | FGFR1 inhibitor-6 (compound 3) (48 h) shows cytotoxic activities with IC50s of 2.06, 0.73, 97.2 μM for HepG-2, MCF-7, WI-38 cells, respectively[1].
FGFR1 inhibitor-6 (0.73 μM; 24 h) induces apoptosis and cell cycle arrest at pre-G1 and G2/M phase[1].
FGFR1 inhibitor-6 (0.73 μM; 24 h) increases the expression of caspase-3/7/9 protein levels in MCF-7 cells[1].
Cell Cytotoxicity Assay[1] | Cell Line: | HepG-2, MCF-7, WI-38 cells | | Concentration: | | | Incubation Time: | 48 h | | Result: | Showed cytotoxic activities with IC50s of 2.06, 0.73, 97.2 μM for HepG-2, MCF-7, WI-38 cells, respectively. |
Cell Cycle Analysis[1] | Cell Line: | MCF-7 cells | | Concentration: | 0.73 μM | | Incubation Time: | 24 h | | Result: | Induced pronounced increase in the cell percentages at pre-G1 and G2/M phase at 27.72% and 19.22%, respectively. |
Apoptosis Analysis[1] | Cell Line: | MCF-7 cells | | Concentration: | 0.73 μM | | Incubation Time: | 24 h | | Result: | Induced apoptosis with late apoptosis percentages are 11.24 % and the early apoptosis percentages from 1.59% to 5.07%. |
Western Blot Analysis[1] | Cell Line: | MCF-7 cells | | Concentration: | 0.73 μM | | Incubation Time: | 24 h | | Result: | Increased the expression of caspase-3/7/9 protein levels with the caspase-3, aspase-7, aspase-9 protein levels increased to 5.60, 11.62, 7.14 folds, respectively comparing with the untreated cells. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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