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Teicoplanin A2-2
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Teicoplanin A2-2图片
CAS NO:91032-26-7
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍

glycopeptide antibiotic

Cas No.91032-26-7
别名替考拉宁A2-2
化学名34-O-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-22,31-dichloro-7-demethyl-64-O-demethyl-19-deoxy-56-O-[2-deoxy-2-[(8-methyl-1-oxononyl)amino]-β-D-glucopyranosyl]-42-O-α-D-mannopyranosyl-ristomycin A aglycone
Canonical SMILESO[C@@H]([C@H](O)[C@@H](CO)O1)[C@H](O)[C@H]1OC2=CC(O)=CC([C@@H](C(O)=O)NC([C@@]([C@@H](C3=CC(Cl)=C(OC4=CC5=CC(OC6=CC=C7C=C6Cl)=C4O[C@H]8[C@H](NC(CCCCCCC(C)C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O8)C=C3)O[C@]9([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9NC(C)=O)([H]
分子式C88H97Cl2N9O33
分子量1879.7
溶解度≤10mg/ml in DMSO;1mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Teicoplanin A2-2 is a new glycopeptide antibiotic belonging to the same family as vancomycin. Teicoplanin consists of five major components (A2-1 through A2-5), one hydrolysis component (A3-1), and four minor components (RS-1 through RS-4) [1]. Teicoplanin is isolated from the fermentation broth of Actinoplanes teichomyceticus nov. sp. and has been endowed with outstanding bactericidal activity against grampositive pathogenic bacteria [2].

In vitro: Teicoplanin inhibited cell wall synthesis in Bacillus subtilis, the inhibition is accompanied by an intracellular accumulation of UDP-N-acetyl-muramyl-pentapeptide. In a cell-free system from Bacillus stearothermophilus, treatment with teicoplanin (40 μg/ml) inhibited 50% of peptidoglycan synthesis, and 100 μg/ml teicoplanin totally suppressed peptidoglycan synthesis [2].

In vivo: Following intravenous administration, concentrations of teicoplanin were high in lung and bone tissue and low in fat in relative to those in plasma in patients with normal renal function. Animal data showed high concentrations in most tissues, and particularly high in liver and kidneys [3].

References:

[1] Bernareggi A, Borghi A, Borgonovi M, et al. Teicoplanin metabolism in humans[J]. Antimicrobial agents and chemotherapy, 1992, 36(8): 1744-1749.

[2] S. Somma, L. Gastaldo and A. Corti. Teicoplanin, a new antibiotic from Actinoplanes teichomyceticus nov. sp. Antimicrobial Agents and Chemotherapy 26(6), 917-923 (1984).

[3] Rowland M. Clinical pharmacokinetics of teicoplanin[J]. Clinical pharmacokinetics, 1990, 18(3): 184-209

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