| CAS NO: | 1414-45-5 |
| 包装 | 价格(元) |
| 1g | 电议 |
| 5g | 电议 |
| 10g | 电议 |
| Cas No. | 1414-45-5 |
| 别名 | 乳酸链球菌素,Ambicin N|Nisaplin? |
| 化学名 | L-isoleucyl-(Z)-2,3-didehydro-2-aminobutanoyl-D-cysteinyl-L- isoleucyl-2,3-didehydroalanyl-L-leucyl-L-cysteinyl-threo-3- mercapto-D-2-aminobutanoyl-L-prolylglycyl-L-cysteinyl-L-lysyl- threo-3-mercapto-D-2-aminobutanoylglycyl-L-alanyl-L-leucyl-L- methionyl |
| Canonical SMILES | O=C(N1[C@@]([H])(CCC1)C(NC2)=O)[C@@H](NC([C@@H](NC([C@H](CC(C)C)NC(C(N3)=C)=O)=O)CSC[C@@H](NC(/C(NC([C@H]([C@H](CC)C)N)=O)=C/C)=O)C(N[C@]([H])(C3=O)[C@H](CC)C)=O)=O)[C@H](C)SC[C@@H](C(N[C@H](C(N[C@@H]([C@H](C)SC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C |
| 分子式 | C143H230N42O37S7 |
| 分子量 | 3354.1 |
| 溶解度 | ≤0.25mg/ml in DMSO |
| 储存条件 | -20°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Nisin A is an antibacterial peptide. Nisin A is produced by the lactic acid bacterium L. lactis using uncommon amino acids, including lanthionine, and is a member of the class of antibiotics referred to as lantibiotics. In vitro: Previous study showed that the sperm motility could be completely inhibited with nisin A. The minimum effective concentration of nisin A required to immobilize sperm in vitro within 20 s was found to be 50 microg in rat, 200 microg in rabbit and 300-400 microg in monkey and human. Such inhibitory effect on sperm motility was found to be dose- and time-dependent [1]. In vivo: Intravaginal administration of nisin A before mating during proestrus-estrous transition phase caused complete arrest of sperm motility and blockage of conception. Subacute toxicity studies in rats showed that, repetitive intravaginal application of nisin A at the dose of 200 microg for 14 days caused no abnormalities either in the length of estrous cycle or in the morphology of vaginal epithelial cells. Moreover, no histopathological abnormalities in vaginal tissue or any change in blood and serum biochemical profiles were seen. In addition, no adverse effects were found on subsequent reproductive performance, development of pups and neonate survival [1]. Clinical trial: Up to now, nisin A is still in the preclinical development stage. Reference: |
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