| CAS NO: | 58331-17-2 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 25mg | 电议 |
| Cas No. | 58331-17-2 |
| 别名 | 海南霉素,4-Methylsalinomycin,Monteban,Narasin A |
| 化学名 | 4S-methyl-salinomycin, monosodium salt |
| Canonical SMILES | C[C@@H]1[C@@]([C@@H](C)[C@H](O)[C@H](C)C([C@@H]([C@]2([H])[C@@H](C)C[C@@H](C)[C@]3(O[C@@]4(CC[C@]([C@@]5([H])CC[C@@](CC)(O)[C@H](C)O5)(C)O4)[C@H](O)C=C3)O2)CC)=O)([H])O[C@]([C@@H](CC)C([O-])=O)([H])[C@@H](C)C1.[Na+] |
| 分子式 | C43H71O11o Na |
| 分子量 | 787 |
| 溶解度 | DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IC50: 3.2 μM: blocks NF-κB signaling via inhibition of IκBα phosphorylation Narasin, isolated from certain Streptomyces sp. is an ionophore antibiotic. As a coccidiostat, it can be used in veterinary practice for gastrointestinal parasites. Narasin has been shown to induce tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and to dampen NF-κB signaling by suppressing the phosphorylation of IκBα. NF-κB, as a transcription factor, plays a vital role across many cellular processes which are involved in neuronal and embryonic development, cell proliferation, apoptosis, and immune responses to infection and inflammation. In vitro: Narasin caused suicidal erythrocyte death or eryptosis. When human erythrocytes were exposed to narasin, it was shown that narasin resulted in the increase of annexin-V-binding indicating cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface and the decrease of forward scatter reflecting cell shrinkage, which indicated the death of erythrocyte [1]. Narasin blocked NF-κB signaling via inhibition of IκBα phosphorylation at a lower concentration [2]. In vivo: New Zealand White rabbits were given narasin 4-48 p. p. m, in pelleted feed. After 4 weeks, the experiments indicated that narasin protected rabbits from severe coccidiosis induced by E. flavescens, E. perforans E. magna, E. intestinalis, and E. stiedai. In addition, narasin reduced oocyst output in a highly effective fashion [3]. References: |
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