| CAS NO: | 1443461-21-9 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 25mg | 电议 |
| Cas No. | 1443461-21-9 |
| Canonical SMILES | CC(C(C(C[C@@]([C@](O)([H])CN(CC1=CC=C(Cl)C=C1)CCN(C)C)2CC[C@]34C)=O)=C2[C@@]3([H])CC[C@]5([H])[C@]6(CC[C@@](OC(CC(C)(C(O)=O)C)=O)([H])C(C)(C6([H])CC[C@]54C)C)C)C |
| 分子式 | C48H73ClN2O6 |
| 分子量 | 809.56 |
| 溶解度 | DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: 1 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | GSK2838232 is an HIV-1 maturation inhibitor [1] [2]. HIV-1 maturation inhibitors disrupt the cleavage of the HIV-1 gag protein immediate precursor by the enzyme HIV-1 protease. Maturation inhibitors bind the gag protein, which leads to the formation of immature, noninfectious virus particles incapable of infecting other cells. Also, maturation inhibitors inhibit HIV infections with resistance. GSK2838232 is a HIV-1 maturation inhibitor and is active against a broad range of isolates, including those resistant to bevirimat [1]. GSK2838232 was developed for the treatment of chronic HIV infection. A phase I study in HIV-negative individuals had been completed. Single doses of 5, 10 or 20 mg GSK2838232 were used to evaluate the initial safety, tolerability, pharmacokinetics profile, and the effects of food and ritonavir on GSK2838232’s bioavailability and pharmacokinetics [2]. References: |
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