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Amylin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amylin图片
CAS NO:122384-88-7
包装:500μg
市场价:1932元

产品介绍
胰淀素是一种 37 个氨基酸的多肽,是一种与胰岛素共同分泌的胰腺激素,在新陈代谢和葡萄糖稳态中发挥独特的作用。
Cas No.122384-88-7
别名糖尿病相关肽(胰岛淀粉样肽)(抗原),DAP amide, human
分子式C165H261N51O55S2
分子量3903.33
溶解度Soluble to 5 mg/ml in Water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Amylin, amide, human, a 37-amino acid polypeptide, is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. Amylin, amide, human inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent[1].

MCF-7 cells endogenously express human amylin receptor CTR1 and CTR2. Stimulation of the receptor with Amylin, amide, human results in the production of cAMP. Amylin, amide, human (0.001 nM-1000 μM) results in an EC50 of 35.2±7.5 nM[1].

Amylin, amide, human (400 μg peptide /kg body weight) is injected by subcutaneous route in separated groups of swiss male mice. A typical PK curve for the free amylin is observed, with a half-time of 23 min[1].

References:
[1]. Sisnande T, et al. Monoconjugation of Human Amylin with Methylpolyethyleneglycol. PLoS One. 2015 Oct 8;10(10):e0138803.