Henatinib

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Henatinib

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1239269-51-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Henatinib 是一种口服有效的小分子多激酶抑制剂，具有广泛的抗肿瘤活性。Henatinib 抑制VEGFR-2、c-kit、PDGFR的活性，IC₅₀值分别为 0.6 nM、3.3 nM 和 41.5 nM。Henatinib 显著抑制人脐静脉内皮细胞 (HUVECs) 中的 VEGFR-2 磷酸化及其下游信号通路。

生物活性

Henatinib is an orally active small-molecule multikinase inhibitor that has demonstrated broad and potent antitumor activities. Henatinib inhibits the activity ofVEGFR-2,c-kit,PDGFRwithIC₅₀values of 0.6 nM, 3.3 nM and 41.5 nM, respectively. Henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signal pathway in human umbilical vein endothelial cells (HUVECs)^[1].

IC₅₀& Target

VEGFR-2

0.6 nM (IC₅₀)

PDGFRα

PDGFRβ

体外研究
(In Vitro)

Henatinib shows high binding affinities for VEGFRs, PDGFR and stem cell factor receptor^[1].
Henatinib significantly inhibits VEGFR-2 phosphorylation and its downstream signal pathway in human umbilical vein endothelial cells (HUVECs), and consistently inhibited VEGF-stimulated HUVEC proliferation, migration and tubule formation^[2].

Clinical Trial

分子量

468.52

Formula

C₂₅H₂₉FN₄O₄

CAS 号

1239269-51-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.