Robotnikinin

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Robotnikinin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1132653-79-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Robotnikinin 是一个能够结合和抑制 Smo上游Sonic Hedgehog (Shh)信号的小分子。

生物活性

Robotnikinin is a small molecule capable of binding to and inhibiting the activity ofSonicHedgehog(Shh)signaling up stream ofSmo^[1]^[2].

体外研究
(In Vitro)

Robotnikinin demonstrates ShhN-binding capacity at concentrations between 1.56 μM and 25 μM, with a K_Dof 3.1 μM derived from kinetic data^[2].
Robotnikinin (50 μM) prevents the ShhN-induced LC3-II increase^[3].
Robotnikinin (5 μM) downregulates classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells, suggesting a link between Hh signaling and the NF-κB pathway in MM^[4].

RT-PCR^[4]

Cell Line:	NCI-H929 or U266 cells.
Concentration:	5 μM.
Incubation Time:	48 h.
Result:	Downregulated classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells.

分子量

454.95

Formula

C₂₅H₂₇ClN₂O₄

CAS 号

1132653-79-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.