Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependentPKAI and II(K_is of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases^{[1][2][3][4][5][6]}.

Ki: 6.05 μM (PKA I) and 9.75 μM (PKA II)^[1]

A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission^[2].

Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons^[2].

345.27

C₁₀H₁₂N₅O₅PS

73208-40-9

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Please store the product under the recommended conditions in the Certificate of Analysis.