LEQ506

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LEQ506

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1204975-42-7

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品名称

NVP-LEQ506

产品介绍

LEQ506 是第二代 smoothened (smo) 抑制剂，在人类和小鼠中的IC₅₀值分别为 2 和 4 nM。

生物活性

LEQ506 is a second-generation inhibitor ofsmoothened(Smo) withIC₅₀s of 2 and 4 nM in human and mouse, respectively.

IC₅₀& Target

IC50: 2 nM (human smo), 4 nM (mouse smo)^[1]

体外研究
(In Vitro)

LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC₅₀s of 2 and 4 nM in human and mouse, respectively. LEQ506 inhibits Hedgehog (Hh) signaling in a human cell line (HEPM) as measured by the amount of Gli mRNA with an IC₅₀~6-fold lower than that of Compound 2^[1]. LEQ506 is an efficacious compound by consistently decreasing Gli1 mRNA by about 70 to 80%. LEQ506 shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. LEQ506 (at 1%) is also an efficacious compound with an inhibition of 80 to 90% for Gli1 and of 60 to 70% for Ptch1^[2].

Clinical Trial

分子量

432.56

性状

Solid

Formula

C₂₅H₃₂N₆O

CAS 号

1204975-42-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL(231.18 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.3118 mL	11.5591 mL	23.1182 mL
5 mM	0.4624 mL	2.3118 mL	4.6236 mL
10 mM	0.2312 mL	1.1559 mL	2.3118 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。