SC 51089 free base

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SC 51089 free base

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

146033-03-6

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

SC 51089 free base 是一种选择性的前列腺素受体EP1拮抗剂，对EP1，TP，EP3和FP受体的K_i值分别为 1.3，11.2，17.5 和 61.1 μM。SC 51089 free base 具有神经保护活性。

生物活性

SC 51089 free base is a selective antagonist ofprostaglandin E₂EP1 receptor, withK_is of 1.3, 11.2, 17.5, and 61.1 μM forEP1,TP,EP3, andFPreceptors, respectively. SC 51089 free base exhibits neuroprotective activity^[1]^[2]^[3].

IC₅₀& Target^[1]

EP1

1.3 μM (Ki)

11.2 μM (Ki)

EP3

17.5 μM (Ki)

61.1 μM (Ki)

体外研究
(In Vitro)

SC 51089 free base (5 μM; 24 h) 减弱前列腺素 E2 (PGE2) 诱导的暴露于 t-BuOOH 的神经元细胞死亡^[2]。

体内研究
(In Vivo)

SC 51089 free base (40 μg/kg; infused i.p. for 28 d) 改善 HD 小鼠运动协调和平衡功能障碍，并挽救长期记忆缺陷^[3]。

Animal Model:	R6/1 mouse model of Huntington's disease (HD), from 13 to 18 weeks of age^[3]
Dosage:	40 μg/kg/day
Administration:	Infused i.p. at a rate of 0.11 μL/h during 28 days by osmotic mini-pump system
Result:	Ameliorated motor coordination and balance dysfunction. Rescued long-term memory deficit. Improved the expression of specific synaptic markers. Reduced the number of huntingtin nuclear inclusions in the striatum and hippocampus.

分子量

422.86

Formula

C₂₂H₁₉ClN₄O₃

CAS 号

146033-03-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vitro:

DMSO : 100 mg/mL(236.48 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.3648 mL	11.8242 mL	23.6485 mL
5 mM	0.4730 mL	2.3648 mL	4.7297 mL
10 mM	0.2365 mL	1.1824 mL	2.3648 mL