Dehydroevodiamine

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Dehydroevodiamine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

67909-49-3

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
20mg	电议

产品介绍

Dehydroevodiamine 是从吴茱萸Evodiae Fructus中分离出的喹唑啉生物碱，对豚鼠心室肌细胞具有抗心律失常作用。Dehydroevodiamine 抑制 LPS 诱导的小鼠巨噬细胞中iNOS，COX-2，PGE2和NF-κB的表达。

生物活性

Dehydroevodiamine is a major bioactive quinazoline alkaloid isolated fromEvodiae Fructus, has an antiarrhythmic effect in guinea-pig ventricular myocytes^[1]. Dehydroevodiamine inhibits LPS-inducediNOS,COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells^[2].

IC₅₀& Target

iNOS

体外研究
(In Vitro)

Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages^[2].
Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS-induced increase in the iNOS and COX-2 mRNA expression^[2].

Western Blot Analysis^[2]

Cell Line:	RAW 264.7 macrophage cells
Concentration:	10 μM, 30 μM, 50 μM
Incubation Time:	pretreated 2 hours
Result:	Reduced iNOS and COX-2 expression and increased IκB-α expression.

RT-PCR^[2]

Cell Line:	RAW 264.7 macrophage cells
Concentration:	10 μM, 30 μM, 50 μM
Incubation Time:	pretreated 2 hours
Result:	Reduced iNOS and COX-2 mRNA expression.

分子量

301.34

Formula

C₁₉H₁₅N₃O

CAS 号

67909-49-3

结构分类

Alkaloids
Indole Alkaloids

来源

Plants
Rutaceae
Evodia rutaecarpa(Juss.) Benth.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

In Vitro:

DMSO : 8.33 mg/mL(27.64 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.3185 mL	16.5926 mL	33.1851 mL
5 mM	0.6637 mL	3.3185 mL	6.6370 mL
10 mM	0.3319 mL	1.6593 mL	3.3185 mL