Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist ofFZD7 receptors, selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. TheEC₅₀values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids^[1][2].

EC50: 58 nM (human FZD7 CRD), 34 nM (mouse FZD7 CRD)^[1]

Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (0-100μM; 6 h; HEK293-TB cells) impairs Wnt signaling with IC₅₀value of 100 nM^[1].
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (1 μM) blocks WNT3A-mediated stabilization of β-catenin in mouse L cells with IC₅₀value of 50 nM^[1].
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) (200 μM; 48 h; LGR5–GFP⁺stem cells) disrupts LGR⁵⁺stem cell function^[1].

1796.05

C₈₃H₁₁₄N₁₈O₂₃S₂

2247635-23-8

Ac-LPSDDLEFWCHVMY-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.