NLS-StAx-h

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NLS-StAx-h

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装:

100 μg

产品介绍

NLS-StAx-h 是选择性的、细胞可渗透的Wnt信号传导的固定肽抑制剂，IC₅₀为 1.4 μM。NLS-StAx-h 可有效抑制 β-catenin-转录因子的相互作用，具有对癌细胞的抗增殖活性。

生物活性

NLS-StAx-h is a selective, cell permeable, stapled peptideWntsignaling inhibitor with anIC₅₀of 1.4 μM. NLS-StAx-h efficiently inhibits β-catenin-transcription factor interactions. NLS-StAx-h shows anti-proliferation ofcancercells^[1]^[2].

IC₅₀& Target

IC₅₀: 1.4 μM (Wnt)^[1]

体外研究
(In Vitro)

NLS-StAx-h (10 μM; 72 h) inhibits proliferation of colorectal cancer cells^[1].
NLS-StAx-h (5 and 10 μM; 24 h) inhibits migration of colorectal cancer cells^[1].

Cell Proliferation Assay^[1]

Cell Line:	SW-480 and DLD-1 cells
Concentration:	10 μM
Incubation Time:	72 hr
Result:	Reduced the viability of both SW-480 and DLD-1 by more than 80%.

Cell Migration Assay^[1]

Cell Line:	DLD-1 cells
Concentration:	5 and 10 μM
Incubation Time:	24 hr
Result:	Resulted in dose-dependent inhibition of wound closure (wound closure: 52% at 5 μM, and 24% at 10 μM).

分子量

3445.26

Formula

C₁₆₁H₂₇₅N₅₅O₂₉

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.