TDI-011536

立即咨询

TDI-011536

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2687970-96-1

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

TDI-011536 是一种有效的Lats激酶抑制剂，能中断Hippo-Yap的信号传导，并可启动受损心肌细胞的增殖。TDI-011536 可用于研究器官的保护和再生。

生物活性

TDI-011536 is a potentLats kinaseinhibitor, interruptsHippo-Yapsignaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration^[1].

IC₅₀& Target

Lats kinase^[1].

体外研究
(In Vitro)

TDI-011536 (3 μM; 24 h) reduces Yap phosphorylation and (3 μM; 5 days) induces proliferation of Müller glia in human retinal organoids^[1].

Cell Proliferation Assay^[1]

Cell Line:	human retinal organoids
Concentration:	3 μM
Incubation Time:	24 h, 5 days
Result:	Supressed Yap phosphorylation and promoted Müller glia proliferation.

体内研究
(In Vivo)

TDI-011536 (200 mg/kg; i.p.; once) provides over 4 h of Lats inhibition in the liver, heart, and skin and reduces the amount of pYap for at least 4 h after injection in all three organs^[1].
TDI-011536 (100 mg/kg; i.p.; once daily for 2 or 3 days) shows proliferative effect on cardiomyocytes^[1].

Animal Model:	Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection)^[1].
Dosage:	200 mg/kg
Administration:	Intraperitoneal injections; once.
Result:	Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day.

Animal Model:	Male 8-week-old mice (cryolesion model)^[1].
Dosage:	100 mg/kg
Administration:	Intraperitoneal injections; once daily for 2 or 3 days.
Result:	Promoted cardiomyocytes proliferation.

分子量

364.42

性状

Solid

Formula

C₁₉H₁₆N₄O₂S

CAS 号

2687970-96-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 125 mg/mL(343.01 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.7441 mL	13.7204 mL	27.4409 mL
5 mM	0.5488 mL	2.7441 mL	5.4882 mL
10 mM	0.2744 mL	1.3720 mL	2.7441 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。