Super-TDU TFA

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Super-TDU TFA

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Super-TDU TFA 是一种特异性的YAP拮抗剂，可以靶向 YAP-TEAD 相互作用。Super-TDU TFA 可以抑制胃癌小鼠模型的肿瘤生长。

生物活性

Super-TDU TFA is a specificYAPantagonist targeting YAP-TEADs interaction. Super-TDU TFA suppresses tumor growth in gastriccancermouse model^[1].

体外研究
(In Vitro)

Super-TDU TFA downregulates expression of YAP-TEADs target genes CTGF, CYR61, and CDX2. Super-TDU TFA inhibits cell viability and colony formation of GC cell lines MGC-803, BGC-823, and HGC27^[1].

体内研究
(In Vivo)

Super-TDU TFA (intravenous Injection; 50 μg/kg or 500 μg/kg; per day) markedly decreases the sizes, weights of tumors, and YAP target genes in a dose-dependent manner in mice^[1].
Super-TDU TFA (Intravenous Injection; 250 μg/kg 500 μg/kg) has the t_1/2αof 0.78 hours and 0.82 hours; the C_maxof 6.12 ng/mL and 13.3 ng/mL; the CL of 7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively^[1].

Animal Model:	BALB/cA nu/nu mice^[1]
Dosage:	50 μg/kg or 500 μg/kg
Administration:	Intravenous Injection; per day
Result:	Decreased the sizes, weights of tumors, and YAP target genes in a dose-dependent manner.

Animal Model:	BALB/cA nu/nu mice^[1]
Dosage:	250 μg/kg or 500 μg/kg (Pharmacokinetic Study)
Administration:	Intravenous Injection
Result:	The t_1/2αis 0.78 hours and 0.82 hours; the C_maxis 6.12 ng/mL and 13.3 ng/mL; the CL is7.41 ml/min/kg and 7.72 ml/min/kg for 250 μg/kg and 500 μg/kg in mice, respectively.

分子量

5393.96

Formula

C₂₃₉H₃₇₁N₆₆O₇₁S

Sequence Shortening

SVDDHFAKSLGDTWLQIGGSGNPKTANVPQTVPMRLRKLPDSFFKPPE

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.