| CAS NO: | 1587727-31-8 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 生物活性 | PF-06648671 is a novel, brain-penetrable, and orally activeγ-secretasemodulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease[1]. | |||||||||
| IC50& Target | IC50: γ-secretase[1] | |||||||||
| 体外研究 (In Vitro) | In a cell-based assay, PF-06648671 reduces Aβ42 and Aβ40 , with concomitant increases in Aβ37 and Aβ38, without inhibiting the cleavage of Notch or other substrates[1]. | |||||||||
| 体内研究 (In Vivo) | PF-06648671 demonstrates reduces Aβ42 within the brain and CSF following acute oral administration in animals[1]. | |||||||||
| Clinical Trial | ||||||||||
| 分子量 | 538.92 | |||||||||
| 性状 | Solid | |||||||||
| Formula | C25H23ClF4N4O3 | |||||||||
| CAS 号 | 1587727-31-8 | |||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | |||||||||
| 储存方式 |
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